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Chronic Toxicity of Chloroform to Japanese Medaka Fish

By Hoffmann, Florence J.

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Book Id: WPLBN0000077714
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title: Chronic Toxicity of Chloroform to Japanese Medaka Fish  
Author: Hoffmann, Florence J.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Hoffmann, F. J. (n.d.). Chronic Toxicity of Chloroform to Japanese Medaka Fish. Retrieved from

Government Reference Publication

Excerpt: Chloroform is a common drinking water disinfection by-product. Recently, present U.S. Environmental Protection Agency (U.S. EPA) drinking water standards for chloroform have been scrutinized (1,2): ?Are todays standards based on rodent megadose studies relevant to real world exposures?? Carcinogenic results in these rodent studies were found at concentrations several orders of magnitude higher than the chloroform maximum contaminant level goal (MCLG) of 0 mg/L and the total trihalomethane maximum contaminant level (MCL) of 0.08 mg/L (3). Nontraditional models such as fish can be used to study chloroform-induced toxicity at exposures closer to concentration levels found in drinking water. Fish have been shown to be sensitive to trace levels of contaminants in aquatic media (4?8). As waterdwelling organisms, fish receive dermal exposure through whole-body immersion in the exposure solution. Intake of test material also occurs through feeding and respiration.


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