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Issues in Biochemical Applications to Risk Assessment : Are Short-Term Tests Predictive of in Vivo Tumorigenicity?

By Tennant, Raymond W., Dr.

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Book Id: WPLBN0000679738
Format Type: PDF eBook
File Size: 350,612 KB.
Reproduction Date: 2005

Title: Issues in Biochemical Applications to Risk Assessment : Are Short-Term Tests Predictive of in Vivo Tumorigenicity?  
Author: Tennant, Raymond W., Dr.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Disarmament Documents
Historic
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Publisher: United Nations - Office for Disarmament Affairs (UNODA)

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Tennant, R. W. (n.d.). Issues in Biochemical Applications to Risk Assessment : Are Short-Term Tests Predictive of in Vivo Tumorigenicity?. Retrieved from http://www.worldlibrary.net/


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Government Reference Publication

Excerpt
Excerpt: My commentary is based on a study that we recently completed under the aegis of the National Toxicology Program (NTP). This study was an objective effort to compare results of in vitro tests, which measure mutagenicity in two different systems or clastogenic effects, either as chromosomal aberrations or as sister chromatid exchange, with chemicals that have been adequately tested for carcinogenicity (1). We were able to evaluate chemicals that have, in many cases, been the same batches that were used in the two rodent species for tumorigenicity studies.

 

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